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Typically, iron in the adult body is categorized into two types: functional iron and storage iron ( However, overexpression of HO-1 induces the expression of prohepcidin, leading to decreased levels of FPN1 and promoting iron storage in the form of hemosiderin, which reduces cellular iron export and causes excessive iron accumulation within cells ( 4.1.2 Heme degradation and labile iron release: key roles of HO-1 in iron homeostasis Heme constitutes a highly bioavailable form of dietary iron, predominantly originating from hemoglobin and myoglobin in meat, poultry, and seafood ( 4.1.3 Mitochondrial dysfunction under iron stress: vulnerabilities induced by HO-1 Mitochondria are indispensable for cellular iron utilization and are tightly linked to iron metabolism ( The mitochondrial transcription factor A (TFAM) is essential for mitochondrial DNA replication and transcription ( Figure 3 )

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Data publikacji: Ostatnia aktualizacja: L-karnityna co to za substancja

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Ruiz NAL, Del ngel DS, Brizuela NO, Peraza AV, Olgun HJ, Soto MP, Guzmn DC (2022) Inflammatory process and immune system in major depressive disorder